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Regulation of Mitochondrial Function by Bioactive Sphingolipids

Received: 24 November 2014     Accepted: 18 December 2014     Published: 10 February 2015
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Abstract

Sphingolipids such as ceramide, sphingosine and sphingosine 1-phosphate [S1P] are key regulators of various cellular functions. Sphingolipids mediates of cell-stress responses and regulate mitochondrial function. Ceramide and its metabolites play an important role in the development and progression of mitochondria related disorders. Ceramide functions as an important second messenger in apoptosis signaling and is generated by de novo synthesis, sphingomyelin hydrolysis, or recycling of sphingolipids. S1P, a potent signaling sphingolipid exerts myriads of pathophysiological function, including lymphocyte trafficking, angiogenesis, vascular development and inflammation. This review is focused on the role of signaling sphingolipids, such as S1P, sphingosine, and ceramide-1 phosphate on mitochondrial function, particularly mitochondrial respiratory function, apoptosis and calcium homeostasis. Further, we discuss the role of sphingolipids in mitochondrial diseases and targeting them for drug development. This review article is a part of special issue on Mitochondria: Implications in human health and disease.

Published in Cell Biology (Volume 3, Issue 2-1)

This article belongs to the Special Issue Mitochondria: Implications in Human Health and Diseases

DOI 10.11648/j.cb.s.2015030201.11
Page(s) 1-7
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Sphingolipid, Ceramide, Sphingosine-1-Phosphate [S1P], Mitochondria, Apoptosis

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    Rajeev Nema, Ashok Kumar. (2015). Regulation of Mitochondrial Function by Bioactive Sphingolipids. Cell Biology, 3(2-1), 1-7. https://doi.org/10.11648/j.cb.s.2015030201.11

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    Rajeev Nema; Ashok Kumar. Regulation of Mitochondrial Function by Bioactive Sphingolipids. Cell Biol. 2015, 3(2-1), 1-7. doi: 10.11648/j.cb.s.2015030201.11

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    AMA Style

    Rajeev Nema, Ashok Kumar. Regulation of Mitochondrial Function by Bioactive Sphingolipids. Cell Biol. 2015;3(2-1):1-7. doi: 10.11648/j.cb.s.2015030201.11

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  • @article{10.11648/j.cb.s.2015030201.11,
      author = {Rajeev Nema and Ashok Kumar},
      title = {Regulation of Mitochondrial Function by Bioactive Sphingolipids},
      journal = {Cell Biology},
      volume = {3},
      number = {2-1},
      pages = {1-7},
      doi = {10.11648/j.cb.s.2015030201.11},
      url = {https://doi.org/10.11648/j.cb.s.2015030201.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cb.s.2015030201.11},
      abstract = {Sphingolipids such as ceramide, sphingosine and sphingosine 1-phosphate [S1P] are key regulators of various cellular functions. Sphingolipids mediates of cell-stress responses and regulate mitochondrial function. Ceramide and its metabolites play an important role in the development and progression of mitochondria related disorders. Ceramide functions as an important second messenger in apoptosis signaling and is generated by de novo synthesis, sphingomyelin hydrolysis, or recycling of sphingolipids. S1P, a potent signaling sphingolipid exerts myriads of pathophysiological function, including lymphocyte trafficking, angiogenesis, vascular development and inflammation. This review is focused on the role of signaling sphingolipids, such as S1P, sphingosine, and ceramide-1 phosphate on mitochondrial function, particularly mitochondrial respiratory function, apoptosis and calcium homeostasis. Further, we discuss the role of sphingolipids in mitochondrial diseases and targeting them for drug development. This review article is a part of special issue on Mitochondria: Implications in human health and disease.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - Regulation of Mitochondrial Function by Bioactive Sphingolipids
    AU  - Rajeev Nema
    AU  - Ashok Kumar
    Y1  - 2015/02/10
    PY  - 2015
    N1  - https://doi.org/10.11648/j.cb.s.2015030201.11
    DO  - 10.11648/j.cb.s.2015030201.11
    T2  - Cell Biology
    JF  - Cell Biology
    JO  - Cell Biology
    SP  - 1
    EP  - 7
    PB  - Science Publishing Group
    SN  - 2330-0183
    UR  - https://doi.org/10.11648/j.cb.s.2015030201.11
    AB  - Sphingolipids such as ceramide, sphingosine and sphingosine 1-phosphate [S1P] are key regulators of various cellular functions. Sphingolipids mediates of cell-stress responses and regulate mitochondrial function. Ceramide and its metabolites play an important role in the development and progression of mitochondria related disorders. Ceramide functions as an important second messenger in apoptosis signaling and is generated by de novo synthesis, sphingomyelin hydrolysis, or recycling of sphingolipids. S1P, a potent signaling sphingolipid exerts myriads of pathophysiological function, including lymphocyte trafficking, angiogenesis, vascular development and inflammation. This review is focused on the role of signaling sphingolipids, such as S1P, sphingosine, and ceramide-1 phosphate on mitochondrial function, particularly mitochondrial respiratory function, apoptosis and calcium homeostasis. Further, we discuss the role of sphingolipids in mitochondrial diseases and targeting them for drug development. This review article is a part of special issue on Mitochondria: Implications in human health and disease.
    VL  - 3
    IS  - 2-1
    ER  - 

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Author Information
  • Department of Biochemistry, All India Institute of Medical Sciences (AIIMS) Bhopal, Saket Nagar, Bhopal 462020, India

  • Department of Biochemistry, All India Institute of Medical Sciences (AIIMS) Bhopal, Saket Nagar, Bhopal 462020, India

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